Xiaoge Zhang, PhD
HEOR Technical Portfolio & Knowledge Base
Bridging Academic Econometrics with Industrial HTA Standards
A professional showcase of high-fidelity health economic modeling, Bayesian evidence synthesis, and real-world causal inference, tailored for advanced HTA applications and NICE/SMC submissions.
🚀 Flagship Case Studies
NICE TA975 (CAR-T) Case Study
Full Submission Replication
A complete end-to-end reconstruction of a CAR-T therapy appraisal (Tisagenlecleucel). Features state-transition modeling, parametric survival fitting, and ICER calculations via Patient Access Schemes (PAS).
ML-NMR Reconstruction
Population Alignment & Synthesis
A deep dive into Multilevel Network Meta-Regression. Solves the “Extrapolation Gap” using 64-point Sobol integration and Cholesky decomposition to bridge IPD and AgD seamlessly in a Bayesian framework.
📚 The Technical Library
Evidence Synthesis & NMA Knowledge Base
A comprehensive suite of technical guidelines and code templates for diverse Network Meta-Analysis challenges.
Fundamentals
Population Adjust
Advanced Synthesis
🛠️ Tech Stack & Methodologies
R (HEEMOD, multinma, tidyverse) Stan / Bayesian Inference Excel (VBA / PowerQuery) NICE DSU TSD Guidelines SuperLearner / TMLE