Xiaoge Zhang, PhD
HEOR Technical Portfolio & Knowledge Base
Bridging Academic Econometrics with Industrial HTA Standards
A professional showcase of high-fidelity health economic modeling, Bayesian evidence synthesis, and real-world causal inference, tailored for advanced HTA applications and NICE/SMC submissions.
π Flagship Case Studies
NICE TA1092 (Pembro) Case Study
Mock Case β Extrapolation Audit & Spline Sensitivity
An EAG-style forensic audit of survival extrapolations (standard parametric vs. flexible splines), treatment-effect waning (5-7 years), and curve-crossing capping, using Guyot-reconstructed patient-level data.
NICE TA975 (CAR-T) Case Study
Full Submission Replication
A complete end-to-end reconstruction of a CAR-T therapy appraisal (Tisagenlecleucel). Features state-transition modeling, parametric survival fitting, and ICER calculations via Patient Access Schemes (PAS).
ML-NMR: AML Population Alignment (TA1013)
Mock Case β Population Alignment & Synthesis
A synthetic-data deep dive into Multilevel Network Meta-Regression. Solves the βExtrapolation Gapβ using 64-point Sobol integration and Cholesky decomposition to bridge IPD and AgD seamlessly in a Bayesian framework.
RWE External Control Arm: R/R DLBCL
Mock Case β Doubly Robust Causal Inference Pipeline
A synthetic-data methodological showcase of External Control Arm construction for a fictional NICE appraisal. Implements IPTW, TMLE (doubly robust estimation), and E-value sensitivity analysis β aligned with the NICE RWE Framework (2022).
PSM: Survival Extrapolation in RRMM
Mock Case β Treatment Effect Waning & Recursive Hazard Chaining
A synthetic-data deep dive into long-term survival extrapolation in a Partitioned Survival Model. Contrasts Naive HR Switching (the Hazard Cliff) against Recursive Hazard Chaining, with full cost-effectiveness analysis and PSA.
π Market Access Decision Tools
Interactive Budget Impact Model
Market Access Decision Tool β Simulated Oncology Therapy
A browser-based budget impact simulator demonstrating how a conventional BIA structure translates into a payer-facing decision-support tool. Covers population funnel, 5-year uptake, PAS discount scenarios, comparator displacement, one-way sensitivity analysis, and cumulative affordability planning β all with live interactive inputs.
π The Technical Library
NMA & Evidence Synthesis Library
A comprehensive suite of technical guidelines and code templates for diverse Network Meta-Analysis challenges.
Population Adjust
Advanced Synthesis
Real-World Evidence & Causal Inference Library
Methodological guidelines and implementation templates for causal inference, confounding adjustment, and external control arms.
RWE Methodology
A focused library of methodological frameworks, implementation guides, and causal inference templates for observational studies, aligned with the 2022 NICE RWE Framework.
π οΈ Tech Stack & Methodologies
R (HEEMOD, multinma, tidyverse) Stan / Bayesian Inference Excel (VBA / PowerQuery) NICE DSU TSD Guidelines SuperLearner / TMLE